• Email
  • Single Page
  • Print

Most of Us Are Part Neanderthal

mithen_1-040314.jpg
Field Museum Library/Getty Images
A diorama of a Neanderthal family cooking mussels near the Devil’s Tower rock shelter at Gibraltar, on the Mediterranean Sea; from the Field Museum, Chicago, early 1970s

My wife has always worried about me going bald, because I have a bump on the back of my skull that if exposed would make me look like a Neanderthal. Common knowledge still maintains that Neanderthals were rather stupid when compared to Homo sapiens, the species we all belong to today. There is, or was, a “gap” between them and us, rather like the gap that Thomas Suddendorf writes about when comparing the mental abilities of modern humans and the great apes. When I used to lecture on human evolution, my hand would involuntarily stroke my head to feel my “occipital bun” just as I mentioned those words to describe a key anatomical difference between Homo sapiens and Homo neanderthalensis. Should I just offer myself as a live demonstration?

My wife need worry no more and my students have had a lucky escape. By finding the lost genome, the Swedish biologist Svante Pääbo has discovered that we are all part Neanderthal—except those with an entirely African heritage. So I now feel like shaving my head to celebrate the interspecies engagement of 50,000 years ago, whether or not it is the ultimate cause for the oddity of my skull and my occasional acts of stupidity.

Archaeologists and physical anthropologists have long debated the evolutionary relationship between modern humans and Neanderthals, relying on the similarities and differences between their designs of stone artifacts and the shapes of their bones, with little real understanding of how these might have arisen. Interminable academic arguments have been swept away by the revolution in studies of ancient DNA, led by Pääbo (now at the Max Planck Institute in Leipzig) and brilliantly recounted in his new book, Neanderthal Man: In Search of Lost Genomes.

Pääbo has provided us with a fabulous account of three decades of research into ancient DNA, culminating in 2010 with the publication of the Neanderthal genome. It’s a story seen through his eyes. He describes how he began with secretive attempts to explore whether DNA would survive in an artificially mummified calf’s liver, and how he led a multimillion-dollar global research project to ascertain the genomes of ancient organisms.

Pääbo’s book has to be compared to The Double Helix (1968), James Watson’s brilliant but controversial account of how the structure of DNA was discovered. When taken together they provide an insight into how biomolecular science has both changed and remained much the same during the last half-century. Both are strong personal accounts of scientific discovery, exposing how science is driven as much by passion, ambition, and competition as by rational thought and the sharing of knowledge. In both books the reader is gripped by life stories of far greater interest than those in many novels before being plunged into passages of near-unintelligible science (despite much simplification) that are nevertheless strangely enthralling.

Pääbo comes across as a generous scientist compared to the distinctly unlikable Watson of The Double Helix. Unlike Watson’s frequent disparaging of others, Pääbo criticizes chiefly those who make “outlandish” and “ludicrous” claims regarding the extraction of DNA from fossils that are millions of years old, obstructionist museum curators, and occasionally himself.

The pressure to publish was present in both worlds. For Pääbo it was especially intense, and partly self-inflicted. One of the reasons he became disillusioned with his early interest, during the 1980s, in Egyptology and archaeology was the “glacial speed” with which the journals “concerned with ancient things” were moving. By the time his article on the extraction of ancient DNA from an Egyptian mummy appeared in the Journal of Archaeological Science in 1985, it had already been overtaken by events, primarily dramatic advances in scientific techniques.

So Pääbo chose to work in a fast-moving field in which journals and prospective authors have to move at an equivalent speed. His decisions about which journals to publish in, when to submit, and what to include in any single paper, along with his reactions to referees’ comments and his responses to the publications of others—sometimes being inspired, at other times distraught—pervade the text as they do the life of any scientist in a fast-moving field today. (Archaeology remains relatively sluggish.) The magnum opus publication of the Neanderthal genome in Science in 2010 had fifty authors. It took up a mere twelve pages in the journal, supported by 174 pages of technical detail in the online supplementary material. An utterly fascinating chapter is devoted to the preparation and reception of the manuscript.

If the pressures, pace, and technical demands of publication have intensified since Watson’s time, the peculiar blend of cooperation and competition between scientists appears much the same. For Watson the competition-cooperation was just down the road at King’s College London and in the Pasadena laboratory of Linus Pauling; for Pääbo and his team, based in the Max Planck Institute, it was Eddy Rubin at Berkeley. He had been a collaborator, but adopted a different method for the sequencing of nuclear DNA than Pääbo, preferring to use the method of cloning bacteria rather than adopting the new polymerase chain reaction (PCR) method. Rubin suffered the consequence of making the wrong choice, becoming little more than a footnote in the story of how ancient DNA was reconstituted (at least as recounted by Pääbo—Rubin might see it differently, as did many of those who read Watson’s book).

The impact of new technology was critical to the successes of both Watson and Pääbo—although far more evident in the latter. Pääbo describes his twenty-five years in molecular biology as a continuous technological revolution. He learned that “unless a person was very, very smart, breakthroughs were best sought when coupled to big improvements in technologies.” Watson and his collaborator Francis Crick are often idealized (notably by Watson himself) as playing with bits of cardboard when building their double helix model for DNA. They could only do so, however, because of the advances in X-ray diffraction that had enabled Rosalind Franklin to create images of DNA that revealed its helical structure. A sneaky look at a single image of Franklin’s by Watson was sufficient.

Pääbo’s dependency on technology was quite different. When hearing about the PCR method at a conference in 1986 he immediately recognized a technical breakthrough for studying ancient DNA. Two decades later, when ready to sequence the three billion nucleotides of the Neanderthal genome, Pääbo required the support of a biotechnology company called 454 Life Sciences, along with several million pounds to pay them. Coincidentally, another project of 454 Life Sciences was “Project Jim,” sequencing the whole genome of James Watson.

While The Double Helix covers just three years (1951–1953) and a single discovery (albeit one on which so much else is based), Pääbo’s search for lost genomes spans three decades and takes the reader through a linked series of discoveries: from the first extraction of Neanderthal DNA to the mapping of the whole Neanderthal genome, the discovery of interbreeding between Neanderthals and Homo sapiens, and the identification of a brand-new human species from ancient DNA that had been extracted from a finger bone found in Denisova Cave in Siberia. Along the way we learn about the extraction of ancient DNA from Egyptian mummies, Oetzi the Bronze Age Ice Man, mammoths, and cave bears. The technical breakthroughs are critical to the story, none more so than those that enabled the shift from studying mitochondrial DNA—i.e., the DNA that is stored in hundreds of copies in a cell’s tiny structures outside its nucleus—to nuclear DNA, two copies of which are stored in the cell’s nucleus. The mitochondrial DNA is inherited from the female line alone and hence provides what Pääbo calls a “blurry, one-eyed view of human history.”

A constant theme of Pääbo’s book is the battle to detect and avoid contamination of ancient DNA by that of modern humans. Such contamination might derive from the archaeologists who innocently handled the bones during excavation or the scientists whose DNA is unavoidably carried on the dust floating through their laboratories. Others should have known better: Pääbo describes his horror at watching a curator at the Natural History Museum in London lick an ancient bone to detect whether it had once been chemically treated, thus coating it with his own DNA. This is one of several moments of human folly interspersed through Pääbo’s account of high-tech science. Quite different is Pääbo’s savoring of the smell of burnt bone when a Neanderthal arm bone was being cut to provide a sample for analysis—the smell suggested that collagen within the bone had survived and hence DNA would be found.

Finding such bones was another challenge for Pääbo, and led to battles with obstructionist museum curators and then negotiations with the Croatian Academy of Sciences and Arts to access the Neanderthal remains from Vindija Cave in the north of the country. Luckily he succeeded, enabling him to find what he describes as a “magic bone,” one that had almost 3 percent of its Neanderthal nuclear DNA preserved, in contrast to the usual frequency of between 0.06 and 0.2 percent. This crushed fragment of bone, five centimeters long, enabled the sequencing of the Neanderthal genome and has changed our understanding of human history. It had sat unremarked upon in a museum basement for several decades.

Throughout this story of ancient DNA we also follow the human story of Pääbo as he drives the science forward, which was by no means a smooth ride. He is an emotional man: on one page we find him overexcited, on another insecure; he is periodically frustrated, irritated, and feels like screaming; he can be very happy and then deeply disappointed. He admits to making a fool of himself, suffering from an exaggerated desire to be liked, bouts of sarcasm (swiftly regretted), and being very sentimental. His emotions are critical to his scientific success and when we read about his brief infatuations with heterosexual men and his pleasure at strolling along a beach naked with his new wife, these passages do not seem inappropriate. His success was not only based on his individual efforts but on building a team of scientists at the Max Planck Institute. He had to manage this team so that each member could pursue his or her own goals while contributing to the big project—budding scientists are, he writes, largely driven by self-interest. When Pääbo writes about how he felt a love for each and every person around the table, one believes him and appreciates that this was crucial to his, and their, success.

What did that success amount to? Pääbo and his team were able to determine that the modern human and Neanderthal lineages had split between 270,000 and 440,000 years ago, a conclusion that confirmed existing views. Far more surprisingly, however, they concluded that people outside of Africa, whether Europeans or Asians, have up to 5 percent of their DNA derived from Neanderthals. The most likely scenario is that a group of modern humans left Africa sometime around 50,000 years ago, interbred with Neanderthals in the Middle East, and then went on to populate the world, taking the Neanderthal DNA with them. That DNA would have been diluted with every generation of humans but its persistence into the present day suggests that some of the Neanderthal gene variants have provided modern humans in Europe and Asia with enhanced adaptive capabilities over their African Homo sapiens forebears.

  • Email
  • Single Page
  • Print